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Article

A non-conservative polymorphism in the IL-6 signal transducer (IL6ST)/gp130 is associated with myocardial infarction in a hypertensive population.

Regulatory peptides - 7 Feb 2008

Benrick Anna, Jirholt Pernilla, Wernstedt Ingrid, Gustafsson Maria, Scheller Juergen, Eriksson Anna-Lena, Borén Jan, Hedner Thomas, Ohlsson Claes, Härd Torleif, Rose-John Stefan, Jansson John-Olov

Abstract excerpt

Inflammation is a key component in the development of atherosclerosis, and myocardial infarction (MI); therefore we investigated the association between an interleukin-6 signal transducer (IL6ST)/gp130 polymorphism, gp130 function and risk of MI. Structural modeling suggested that a non-conservative single nucleotide polymorphism in the gp130, Gly148Arg, can change the stability and functional properties of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17997171
DOI: 10.1016/j.regpep.2007.09.031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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