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Article

Orientational constraints of the gp130 intracellular juxtamembrane domain for signaling.

The Journal of biological chemistry - 26 Jul 2002

Greiser Jens S, Stross Claudia, Heinrich Peter C, Behrmann Iris, Hermanns Heike M

Abstract excerpt

The glycoprotein 130 (gp130) is the common signal transducing receptor chain of the interleukin-6 family of cytokines. Here we investigated the requirements for transfer of the information given by ligand binding to the cytoplasmic domain of gp130. It is demonstrated that the box 1/2 region has to be located membrane-proximally in order to bind and activate Janus kinases. To test the possible requirement of an...

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Source

Identifiers

PMID: 12011064
DOI: 10.1074/jbc.M204113200

Genes

STAT1
STAT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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