Article
A polymorphism at the IL6ST (gp130) locus is associated with traits of the metabolic syndrome.
Obesity (Silver Spring, Md.) - 1 Jan 2008
Gottardo Lucia, De Cosmo Salvatore, Zhang Yuan-Yuan, Powers Christine, Prudente Sabrina, Marescotti Maria C, Trischitta Vincenzo, Avogaro Angelo, Doria Alessandro
Abstract excerpt
The interleukin 6 signal transducer (IL6ST, also known as gp130) is a ubiquitously expressed intermediate of the interleukin-6 signaling pathway. We investigated whether genetic variability at the IL6ST locus is involved in the modulation of metabolic traits and the etiology of the metabolic syndrome (MS). Four haplotype-tagging single nucleotide polymorphisms were typed in two populations of non-diabetic...
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