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Article

Signal transducer of inflammation gp130 modulates atherosclerosis in mice and man.

The Journal of experimental medicine - 6 Aug 2007

Luchtefeld Maren, Schunkert Heribert, Stoll Monika, Selle Tina, Lorier Rachel, Grote Karsten, Sagebiel Christian, Jagavelu Kumaravelu, Tietge Uwe J F, Assmus Ulrike, Streetz Konrad, Hengstenberg Christian, Fischer Marcus, Mayer Björn, Maresso Karen, El Mokhtari Nour Eddine, Schreiber Stefan, Müller Werner, Bavendiek Udo, Grothusen Christina, Drexler Helmut, Trautwein Christian, Broeckel Ulrich, Schieffer Bernhard

Abstract excerpt

Liver-derived acute phase proteins (APPs) emerged as powerful predictors of cardiovascular disease and cardiovascular events, but their functional role in atherosclerosis remains enigmatic. We report that the gp130 receptor, which is a key component of the inflammatory signaling pathway within he...

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Identifiers

PMID: 17664290
DOI: 10.1084/jem.20070120
PMCID: PMC2118681

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CAD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17664290-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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