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Article

Critical cytoplasmic region of the interleukin 6 signal transducer gp130 is conserved in the cytokine receptor family.

15 Dec 1991

Abstract excerpt

Interleukin 6 (IL-6) signal is transduced through gp130 that associates with a complex of IL-6 and IL-6 receptor. Truncations or amino acid substitutions offe introduced in the cytoplasmic region of human gp130, and the mutant cDNAs were transfected into murine interleukin 3-dependent cells to determine amino acid residues critical for generating the IL-6-mediated growth signal. In the 277-amino acid cytoplasmic...

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Identifiers

PMID: 1662392
DOI: 10.1073/pnas.88.24.11349

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Source receipt: pubmed, retrieved 7 Sept 2026.

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