Article
Glycoprotein 130 polymorphism predicts soluble glycoprotein 130 levels.
Metabolism: clinical and experimental - 1 May 2014
Wonnerth Anna, Katsaros Katharina M, Krychtiuk Konstantin A, Speidl Walter S, Kaun Christoph, Thaler Kylie, Huber Kurt, Wojta Johann, Maurer Gerald, Seljeflot Ingebjorg, Arnesen Harald, Weiss Thomas W
Abstract excerpt
OBJECTIVE: Interleukin-6 (IL-6) is a key cytokine in inflammatory diseases. It exerts its biological function via binding to a homodimer of its signal transducer glycoprotein 130 (gp130). Soluble gp130 (sgp130) is the natural inhibitor of IL-6 trans-signalling. The aim of this study was to test a...
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