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Article

RARA and RARG gene downregulation associated with EZH2 mutation in acute promyelocytic-like morphology leukemia.

Human pathology - 1 Oct 2018

Coccaro Nicoletta, Zagaria Antonella, Orsini Paola, Anelli Luisa, Tota Giuseppina, Casieri Paola, Impera Luciana, Minervini Angela, Minervini Crescenzio F, Cumbo Cosimo, Parciante Elisa, Mestice Anna, Delia Mario, Brunetti Claudia, Specchia Giorgina, Albano Francesco

Abstract excerpt

Most acute promyelocytic leukemia (APL) patients express PML-RARA fusion; in rare cases, RARA is rearranged with partner genes other than PML. To date, only 2 patients presenting features similar to APL showing the RARG gene rearrangement have been described. We report an acute myeloid leukemia patient with morphology resembling APL without involvement of the RARA gene. Molecular and fluorescent in situ...

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Source

Identifiers

PMID: 29530751
DOI: 10.1016/j.humpath.2018.02.023

Genes

RARA
RARG
PML

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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