Contractility and phenotype of human bronchiole smooth muscle after prolonged fetal bovine serum exposure.

doi:10.1080/01902140303758

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Article

Contractility and phenotype of human bronchiole smooth muscle after prolonged fetal bovine serum exposure.

Experimental lung research - 1 Sept 2003

Moir Lyn M, Ward Jeremy P T, Hirst Stuart J

Abstract excerpt

Culture of dispersed airway smooth muscle (ASM) cells with fetal bovine serum (FBS) induces rapid growth and modulation from a contractile to a synthetic phenotype, but this may be an artificial situation due to loss of tissue architecture. In this study, structural, functional and biochemical changes of ASM were examined in human intact bronchiole ring segments (200 to 600 micro m internal diameter) after organ...

Topics

Adult
Aged
Antibodies, Monoclonal
Blotting, Western
Bronchi
Carbachol
Contractile Proteins
Culture Media, Serum-Free
Cytoskeletal Proteins
Female
Histamine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Male

Middle Aged

Muscle Contraction

Muscle, Smooth

Organ Culture Techniques

Phenotype

Source

Open in PubMed

Identifiers

PMID: 12888448
DOI: 10.1080/01902140303758

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