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Article

An expanded eukaryotic genetic code.

Science (New York, N.Y.) - 15 Aug 2003

Chin Jason W, Cropp T Ashton, Anderson J Christopher, Mukherji Mridul, Zhang Zhiwen, Schultz Peter G

Abstract excerpt

We describe a general and rapid route for the addition of unnatural amino acids to the genetic code of Saccharomyces cerevisiae. Five amino acids have been incorporated into proteins efficiently and with high fidelity in response to the nonsense codon TAG. The side chains of these amino acids contain a keto group, which can be uniquely modified in vitro and in vivo with a wide range of chemical probes and...

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PMID: 12920298
DOI: 10.1126/science.1084772

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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