Contamination of the genome by very slightly deleterious mutations: why have we not died 100 times over?

doi:10.1006/jtbi.1995.0167

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Article

Contamination of the genome by very slightly deleterious mutations: why have we not died 100 times over?

Journal of theoretical biology - 21 Aug 1995

Kondrashov A S

Abstract excerpt

It is well known that when s, the selection coefficient against a deleterious mutation, is below approximately 1/4Ne, where Ne is the effective population size, the expected frequency of this mutation is approximately 0.5, if forward and backward mutation rates are similar. Thus, if the genome si...

Topics

Animals
Gene Deletion
Genes, Lethal
Genome
Humans
Models, Genetic
Mutation

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