Contamination of the genome by very slightly deleterious mutations: why have we not died 100 times over?

Abstract excerpt

It is well known that when s, the selection coefficient against a deleterious mutation, is below approximately 1/4Ne, where Ne is the effective population size, the expected frequency of this mutation is approximately 0.5, if forward and backward mutation rates are similar. Thus, if the genome size, G, in nucleotides substantially exceeds the Ne of the whole species, there is a dangerous range of selection...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Gene Deletion
• Share to Genes, Lethal
• Share to Genome