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Article

Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system.

Proceedings of the National Academy of Sciences of the United States of America - 18 Jan 2000

Chong M J, Murray M R, Gosink E C, Russell H R, Srinivasan A, Kapsetaki M, Korsmeyer S J, McKinnon P J

Abstract excerpt

Ataxia-telangiectasia is a hereditary multisystemic disease resulting from mutations of ataxia telangiectasia, mutated (ATM) and is characterized by neurodegeneration, cancer, immune defects, and hypersensitivity to ionizing radiation. The molecular details of ATM function in the nervous system are unclear, although the neurological lesion in ataxia-telangiectasia becomes apparent early in life, suggesting a...

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Identifiers

PMID: 10639175
DOI: 10.1073/pnas.97.2.889
PMCID: PMC15426

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system.PMID 10639175Read ↗

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