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Article

Intrinsic and extrinsic pathway signaling during neuronal apoptosis: lessons from the analysis of mutant mice.

The Journal of cell biology - 29 Apr 2002

Putcha Girish V, Harris Charles A, Moulder Krista L, Easton Rachael M, Thompson Craig B, Johnson Eugene M

Abstract excerpt

Trophic factor deprivation (TFD)-induced apoptosis in sympathetic neurons requires macromolecular synthesis-dependent BAX translocation, cytochrome c (cyt c) release, and caspase activation. Here, we report the contributions of other intrinsic and extrinsic pathway signals to these processes. Sympathetic neurons expressed all antiapoptotic BCL-2 proteins examined, yet expressed only certain BH3-only and...

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Share to bcl-2 Homologous Antagonist-Killer Protein
Share to bcl-Associated Death Protein

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to BH3 Interacting Domain Death Agonist Protein

Share to Cytochrome c Group

Share to Nerve Growth Factors

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Source

Open in PubMed Open full text

Identifiers

PMID: 11980919
DOI: 10.1083/jcb.200110108
PMCID: PMC2173286

Genes

BAD
BAX
BID

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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