Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Intrinsic and extrinsic pathway signaling during neuronal apoptosis: lessons from the analysis of mutant mice.

The Journal of cell biology - 29 Apr 2002

Putcha Girish V, Harris Charles A, Moulder Krista L, Easton Rachael M, Thompson Craig B, Johnson Eugene M

Abstract excerpt

Trophic factor deprivation (TFD)-induced apoptosis in sympathetic neurons requires macromolecular synthesis-dependent BAX translocation, cytochrome c (cyt c) release, and caspase activation. Here, we report the contributions of other intrinsic and extrinsic pathway signals to these processes. Sym...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to bcl-2 Homologous Antagonist-Killer Protein
Share to bcl-Associated Death Protein
Share to BH3 Interacting Domain Death Agonist Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome c Group

Share to Nerve Growth Factors

Share to Neurons

Share to Proto-Oncogene Proteins c-bcl-2

Share to Sympathetic Nervous System

Source

Open in PubMed Open full text

Identifiers

PMID: 11980919
DOI: 10.1083/jcb.200110108
PMCID: PMC2173286

Genes

BAD
BAX
BID

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11980919-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Intrinsic and extrinsic pathway signaling during neuronal apoptosis: lessons from the analysis of mutant mice.PMID 11980919Read ↗

Neuronal cell death in nervous system development, disease, and injury (Review)Semantic proximity Read ↗

Neuron-specific Bcl-2 homology 3 domain-only splice variant of Bak is anti-apoptotic in neurons, but pro-apoptotic in non-neuronal cells.Semantic proximity Read ↗

Inactivation of bcl-2 results in progressive degeneration of motoneurons, sympathetic and sensory neurons during early postnatal development.Semantic proximity Read ↗

Programmed Cell Death in the Developing Nervous SystemSemantic proximity Read ↗

Required roles of Bax and JNKs in central and peripheral nervous system death of retinoblastoma-deficient mice.Semantic proximity Read ↗

Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and DeathSemantic proximity Read ↗

Blocking the mitochondrial apoptotic pathway preserves motor neuron viability and function in a mouse model of amyotrophic lateral sclerosisSemantic proximity Read ↗

Loss of pro-apoptotic BH3-only Bcl-2 family member Bim does not protect mutant Lurcher mice from neurodegeneration.Semantic proximity Read ↗

Bax deficiency prevents the increased cell death of immature neurons in bcl-x-deficient mice.Semantic proximity Read ↗

Bim Is a Direct Target of a Neuronal E2F-Dependent Apoptotic PathwaySemantic proximity Read ↗

<i>bax</i>Deficiency Prevents the Increased Cell Death of Immature Neurons in<i>bcl-x</i>-Deficient MiceSemantic proximity Read ↗

JNK3 contributes to c-Jun activation and apoptosis but not oxidative stress in nerve growth factor-deprived sympathetic neurons.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.