Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Shh Signaling and Pancreatic Cancer: Implications for Therapy?

1 Jul 2007

Abstract excerpt

Hedgehog signaling has been implicated in the development of several human cancers, including small cell lung carcinomas, medulloblastomas, basal cell carcinomas, and digestive tract tumors. Elevated levels of pathway components are observed in pancreatic ductal adenocarcinoma (PDAC) precursor lesions, and these levels increase further as lesions progress to more advanced stages. Yet the mechanisms by which...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatin Remodeling and Cancer
Share to Hedgehog Signaling Pathway Studies
Share to Pancreatic and Hepatic Oncology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17611415
DOI: 10.4161/cc.6.13.4467

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Shh Signaling and Pancreatic Cancer: Implications for Therapy?PMID 17611415Read ↗

Hedgehog/Ras interactions regulate early stages of pancreatic cancer.Semantic proximity Read ↗

Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis.Semantic proximity Read ↗

Hedgehog signaling pathway as a new therapeutic target in pancreatic cancer.Semantic proximity Read ↗

Hedgehog signaling in pancreas development and disease.Semantic proximity Read ↗

Hedgehog Signaling in Pancreatic Fibrosis and CancerSemantic proximity Read ↗

Developmental biology informs cancer: the emerging role of the hedgehog signaling pathway in upper gastrointestinal cancers.Semantic proximity Read ↗

Genome-Wide Screening Reveals an EMT Molecular Network Mediated by Sonic Hedgehog-Gli1 Signaling in Pancreatic Cancer CellsSemantic proximity Read ↗

The Sonic Hedgehog Signaling Network in Development and NeoplasiaSemantic proximity Read ↗

Assessment of the stromal contribution to Sonic Hedgehog‐dependent pancreatic adenocarcinomaSemantic proximity Read ↗

Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesisSemantic proximity Read ↗

Hedgehog inhibition prolongs survival in a genetically engineered mouse model of pancreatic cancerSemantic proximity Read ↗

Inhibition of Hedgehog Signaling Alters Fibroblast Composition in Pancreatic CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.