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Article

Genetic analysis and allele-specific expression of SMAD7 3'UTR variants in human colorectal cancer reveal a novel somatic variant exhibiting allelic imbalance.

Gene - 5 Apr 2023

Rosic Jovana, Miladinov Marko, Dragicevic Sandra, Eric Katarina, Bogdanovic Aleksandar, Krivokapic Zoran, Nikolic Aleksandra

Abstract excerpt

BACKGROUND: Considering the impact of SMAD7 deregulation in colorectal cancer (CRC) progression and the significance of single nucleotide variant (SNV)-mediated disruptions of microRNA (miRNA)-dependent regulation for cancer susceptibility, our study aimed to analyze genetic variation in the SMAD7 3' untranslated region ( 3'UTR) in CRC, measure differences in allelic mRNA expression, and evaluate its interference...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36690223
DOI: 10.1016/j.gene.2023.147217

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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