Article
Transcriptional regulation of Alzheimer's disease genes: implications for susceptibility.
Human molecular genetics - 1 Oct 2000
Theuns J, Van Broeckhoven C
Abstract excerpt
In recent years, important progress has been made in uncovering genes implicated in Alzheimer's disease (AD). Three causal genes have been identified in which mutations cause familial presenile AD: the amyloid precursor protein gene and the presenilin 1 and 2 genes. Additionally, the epsilon 4 allele of the apolipoprotein E gene was shown to be a major risk factor for AD. Despite the genetic heterogeneity, all of...
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