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Article

Transcriptional regulation and its misregulation in Alzheimer’s disease

1 Jan 2013

Abstract excerpt

Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by loss of memory and cognitive function. A key neuropathological event in AD is the accumulation of amyloid-β (Aβ) peptide. The production and clearance of Aβ in the brain are regulated by a large group of genes. The expression levels of these genes must be fine-tuned in the brain to keep Aβ at a balanced amount under...

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PMID: 24144318
DOI: 10.1186/1756-6606-6-44

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