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Article

Role of the Rho GTPase-activating protein RICS in neurite outgrowth.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Jun 2006

Nasu-Nishimura Yukiko, Hayashi Tomoatsu, Ohishi Tomohiro, Okabe Toshio, Ohwada Susumu, Hasegawa Yoshimi, Senda Takao, Toyoshima Chikashi, Nakamura Tsutomu, Akiyama Tetsu

Abstract excerpt

The Rho family of small GTPases, including RhoA, Rac1 and Cdc42, are critical regulators of the actin cytoskeleton. In neuronal systems, Rho GTPase-activating proteins (RhoGAPs) and their substrates, Rho GTPases, have been implicated in regulating multiple processes in the morphological development of neurons, including axonal growth and guidance, dendritic elaboration and formation of synapses. RICS is mainly...

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PMID: 16716191
DOI: 10.1111/j.1365-2443.2006.00966.x

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