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Article

Amiloride-sensitive NaCl taste responses are associated with genetic variation of ENaC alpha-subunit in mice.

American journal of physiology. Regulatory, integrative and comparative physiology - 1 Jan 2008

Shigemura Noriatsu, Ohkuri Tadahiro, Sadamitsu Chiharu, Yasumatsu Keiko, Yoshida Ryusuke, Beauchamp Gary K, Bachmanov Alexander A, Ninomiya Yuzo

Abstract excerpt

An epithelial Na(+) channel (ENaC) is expressed in taste cells and may be involved in the salt taste transduction. ENaC activity is blocked by amiloride, which in several mammalian species also inhibits taste responses to NaCl. In mice, lingual application of amiloride inhibits NaCl responses in the chorda tympani (CT) gustatory nerve much stronger in the C57BL/6 (B6) strain than in the 129P3/J (129) strain. We...

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Identifiers

PMID: 17977920
DOI: 10.1152/ajpregu.00420.2007
PMCID: PMC2262045

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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