Article
The microtubule-associated protein doublecortin-like regulates the transport of the glucocorticoid receptor in neuronal progenitor cells.
Molecular endocrinology (Baltimore, Md.) - 1 Feb 2008
Fitzsimons Carlos P, Ahmed Suaad, Wittevrongel Christiaan F W, Schouten Theo G, Dijkmans Thomas F, Scheenen Wim J J M, Schaaf Marcel J M, de Kloet E Ronald, Vreugdenhil Erno
Abstract excerpt
In neuronal cells, activated glucocorticoid receptor (GR) translocates to the nucleus guided by the cytoskeleton. However, the detailed mechanisms underlying GR translocation remain unclear. Using gain and loss of function studies, we report here for the first time that the microtubule-associated protein doublecortin-like (DCL) controls GR translocation to the nucleus. DCL overexpression in COS-1 cells,...
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