Distribution of CYP3A4*1/*1B (rs2740574) and CYP3A5*1/*3 (rs776746) Genetic Variants in Renal Transplant Recipients Treated with Sirolimus in Urmia (Iran).

doi:10.61882/ijkd.3.03.9130

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Article

Distribution of CYP3A41/1B (rs2740574) and CYP3A51/3 (rs776746) Genetic Variants in Renal Transplant Recipients Treated with Sirolimus in Urmia (Iran).

Iranian journal of kidney diseases - 31 May 2026

Makhdoomi Khadijeh, Mivefroshan Azam, Jafari Lale, Ghelich Khan Zahra, Abdi Rad Isa, Bagheri Morteza

Abstract excerpt

Introduction. Rapamycin, also referred to as Sirolimus, is an immunosuppressive medication used in kidney transplantation to prevent organ rejection. Sirolimus is metabolized predominantly by the enzymes CYP3A4 and CYP3A5. The objective of this study was to evaluate the distribution of CYP3A4*1/*1B (rs2740574, -392A > G) and CYP3A5*1/*3 (rs776746, 6986A > G) genetic variants in renal transplant recipients treated...

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Cytochrome P-450 CYP3A
Graft Rejection

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunosuppressive Agents

Iran

Kidney Transplantation

Pharmacogenomic Variants

Polymorphism, Restriction Fragment Length

Sirolimus

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Open in PubMed

Identifiers

PMID: 42234923
DOI: 10.61882/ijkd.3.03.9130

Genes

CYP3A4
CYP3A5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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