Article

Cyclosporin A delays the terminal disease stage in <i>Tfam</i> KO mice without improving mitochondrial energy production

2022-10-18

Abstract excerpt

<h4> A bstract </h4> Mitochondrial myopathies are rare genetic disorders characterized by muscle weakness and exercise intolerance. Currently, no effective treatment exists for these myopathies. Interestingly, the pharmacological cyclophilin inhibitor cyclosporine A (CsA) extended lifespan and prevented loss of force and mitochondrial Ca 2+ overload in muscle fibers in the skeletal muscle-specific Tfam knocko...

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Literature Corpus work: 477147e8-5b63-5a85-b9ec-cb207250b47a
DOI: 10.1101/2022.10.14.511701

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