Article
Calcineurin plays a modulatory role in loading-induced regulation of type I myosin heavy chain gene expression in slow skeletal muscle.
American journal of physiology. Regulatory, integrative and comparative physiology - 1 Oct 2009
Pandorf Clay E, Jiang Weihua H, Qin Anqi X, Bodell Paul W, Baldwin Kenneth M, Haddad Fadia
Abstract excerpt
The role of calcineurin (Cn) in skeletal muscle fiber-type expression has been a subject of great interest because of reports indicating that it controls the slow muscle phenotype. To delineate the role of Cn in phenotype remodeling, particularly its role in driving expression of the type I myosin heavy chain (MHC) gene, we used a novel strategy whereby a profound transition from fast to slow fiber type is...
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