Article
[Thyroid hormones and muscle phenotype: involvement of new signaling pathways].
Journal de la Societe de biologie - 1 Jan 2008
Bigard André-Xavier, Koulmann Nathalie, Bahi Lahoucine, Sanchez Hervé, Ventura-Clapier Renée
Abstract excerpt
Thyroid hormones (TH) are known to control development, body and muscle growth, as well as to determine muscle phenotype in the adult. TH affect muscle properties through nuclear receptors; they act either by a positive or a negative control on target genes that encode proteins accounting for contractile or metabolic phenotypes. Contractile activity and muscle load also affect muscle phenotype; several...
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