Article
Effects of the DRD4 genotype on neural networks associated with executive functions in children and adolescents.
Developmental cognitive neuroscience - 1 Oct 2012
Gilsbach Susanne, Neufang Susanne, Scherag Susann, Vloet Timo D, Fink Gereon R, Herpertz-Dahlmann Beate, Konrad Kerstin
Abstract excerpt
Genetic variants within the dopamine D4 receptor gene (DRD4) are among the strongest and most consistently replicated molecular genetic findings in attentional functioning as well as attention deficit hyperactivity disorder (ADHD). Functionally, the 7-repeat allele of the DRD4-48 base pair repeat gene leads to a sub-sensitive postsynaptic D4 receptor, which is expressed at a particularly high density in the...
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