Article
Estimating Disequilibrium Coefficients.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2017
Vens Maren, Ziegler Andreas
Abstract excerpt
Gametic phase disequilibrium is the nonrandom association of alleles within gametes. Linkage disequilibrium (LD) describes the special case of deviation from independence between alleles at two linked genetic loci. Estimation of allelic LD requires knowledge of haplotypes. Genotype-based LD measures dispense with the haplotype estimation step and avoid bias in LD estimation. In this chapter, the most important...
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