Article
Linkage disequilibrium assessment via log-linear modeling of SNP haplotype frequencies.
Genetic epidemiology - 1 Sept 2003
Morris Andrew, Pedder Alan, Ayres Karen
Abstract excerpt
Analyses of high-density single-nucleotide polymorphism (SNP) data, such as genetic mapping and linkage disequilibrium (LD) studies, require phase-known haplotypes to allow for the correlation between tightly linked loci. However, current SNP genotyping technology cannot determine phase, which must be inferred statistically. In this paper, we present a new Bayesian Markov chain Monte Carlo (MCMC) algorithm for...
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