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Article

Relapsed childhood acute myeloid leukemia patient with inversion of chromosome 16 harboring a low FLT3 internal tandem duplication allelic burden and KIT mutations.

Pediatrics international : official journal of the Japan Pediatric Society - 1 Sept 2016

Yamada Ai, Moritake Hiroshi, Kinoshita Mariko, Sawa Daisuke, Kamimura Sachiyo, Iwamoto Shotaro, Yamashita Yuka, Inagaki Jiro, Takahashi Takahide, Shimada Akira, Obara Megumi, Nunoi Hiroyuki

Abstract excerpt

Inversion of chromosome 16 [inv(16)] has a good prognosis in acute myeloid leukemia (AML), but additional genetic aberrations influence the outcome. We herein describe the case of a 15-year-old Japanese boy with inv(16) harboring a low-allelic burden internal tandem duplication of FLT3 (FLT3-ITD) and KIT mutations. Conventional chemotherapy eradicated a clone with a low-allelic burden FLT3-ITD mutation, although...

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Identifiers

PMID: 27460485
DOI: 10.1111/ped.13010

Genes

FLT3
KIT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Relapsed childhood acute myeloid leukemia patient with inversion of chromosome 16 harboring a low FLT3 internal tandem duplication allelic burden and KIT mutations.PMID 27460485Read ↗

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