Article
Genomic imprinting in mammals: an interplay between chromatin and DNA methylation?
Trends in genetics : TIG - 1 Nov 1999
Feil R, Khosla S
Abstract excerpt
Most imprinted loci have key regulatory elements that are methylated on only one of the parental chromosomes. For several of these 'differentially methylated regions', recent studies establish that the unmethylated chromosome has a specialized chromatin organization that is characterized by nuclease hypersensitivity. The novel data raise the question of whether specific proteins and associated chromatin features...
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