Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tissue-specific Grb10/Ddc insulator drives allelic architecture for cardiac development.

Molecular cell - 6 Oct 2022

Juan Aimee M, Foong Yee Hoon, Thorvaldsen Joanne L, Lan Yemin, Leu Nicolae A, Rurik Joel G, Li Li, Krapp Christopher, Rosier Casey L, Epstein Jonathan A, Bartolomei Marisa S

Abstract excerpt

Allele-specific expression of imprinted gene clusters is governed by gametic DNA methylation at master regulators called imprinting control regions (ICRs). Non-gametic or secondary differentially methylated regions (DMRs) at promoters and exonic regions reinforce monoallelic expression but do not control an entire cluster. Here, we unveil an unconventional secondary DMR that is indispensable for tissue-specific...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Chromatin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Genomic Imprinting

Share to RNA, Long Noncoding

Source

Open in PubMed Open full text

Identifiers

PMID: 36108632
DOI: 10.1016/j.molcel.2022.08.021
PMCID: PMC9547965

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tissue-specific Grb10/Ddc insulator drives allelic architecture for cardiac development.PMID 36108632Read ↗

Allele-specific genomics decodes gene targets and mechanisms of the non-coding genome.Semantic proximity Read ↗

Allele-specific H3K9me3 and DNA methylation co-marked CpG-rich regions serve as potential imprinting control regions in pre-implantation embryo.Semantic proximity Read ↗

A mono-allelic bivalent chromatin domain controls tissue-specific imprinting at Grb10.Semantic proximity Read ↗

Epigenetic control and genomic imprinting dynamics of the Dlk1-Dio3 domainSemantic proximity Read ↗

Biallelic non-productive enhancer-promoter interactions precede imprinted expression of Kcnk9 during mouse neural commitment.Semantic proximity Read ↗

Balanced gene dosage control rather than parental origin underpins genomic imprinting.Semantic proximity Read ↗

Chromosome-wide analysis of parental allele-specific chromatin and DNA methylation.Semantic proximity Read ↗

Genomic imprinting of Dopa decarboxylase in heart and reciprocal allelic expression with neighboring Grb10.Semantic proximity Read ↗

A bipartite element with allele-specific functions safeguards DNA methylation imprints at the <i>Dlk1-Dio3</i> locusSemantic proximity Read ↗

The role of CTCF in the organization of the centromeric 11p15 imprinted domain interactomeSemantic proximity Read ↗

The two-domain hypothesis in Beckwith–Wiedemann syndrome: autonomous imprinting of the telomeric domain of the distal chromosome 7 clusterSemantic proximity Read ↗

The landscape of allelic expression and DNA methylation at the bovine SGCE/PEG10 locus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.