Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DDC and COBL, flanking the imprinted GRB10 gene on 7p12, are biallelically expressed.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Dec 2002

Hitchins Megan P, Bentley Louise, Monk David, Beechey Colin, Peters Jo, Kelsey Gavin, Ishino Fumitoshi, Preece Michael A, Stanier Philip, Moore Gudrun E

Abstract excerpt

Maternal duplication of human 7p11.2-p13 has been associated with Silver-Russell syndrome (SRS) in two familial cases. GRB10 is the only imprinted gene identified within this region to date. GRB10 demonstrates an intricate tissue- and isoform-specific imprinting profile in humans, with paternal expression in fetal brain and maternal expression of one isoform in skeletal muscle. The mouse homolog is maternally...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bromodeoxyuridine
Share to Chromosomes, Human, Pair 7

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dopa Decarboxylase

Share to Fetal Growth Retardation

Share to Gene Duplication

Share to Genomic Imprinting

Share to Microfilament Proteins

Source

Identifiers

PMID: 12514746
DOI: 10.1007/s00335-002-3028-z

Genes

GRB10
DDC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DDC and COBL, flanking the imprinted GRB10 gene on 7p12, are biallelically expressed.PMID 12514746Read ↗

Genomic imprinting of Dopa decarboxylase in heart and reciprocal allelic expression with neighboring Grb10.Semantic proximity Read ↗

Maternal repression of the human GRB10 gene in the developing central nervous system; evaluation of the role for GRB10 in Silver-Russell syndrome.Semantic proximity Read ↗

Human GRB10 is imprinted and expressed from the paternal and maternal allele in a highly tissue- and isoform-specific fashion.Semantic proximity Read ↗

Imprinting of human GRB10 and its mutations in two patients with Russell-Silver syndrome.Semantic proximity Read ↗

Conserved methylation imprints in the human and mouse GRB10 genes with divergent allelic expression suggests differential reading of the same markSemantic proximity Read ↗

Large de novo deletion of 7p15.1 to 7p12.1 involving the imprinted gene GRB10 associated with a complex phenotype including features of Beckwith Wiedemann syndrome.Semantic proximity Read ↗

At Least Ten Genes Define the Imprinted Dlk1-Dio3 Cluster on Mouse Chromosome 12qF1Semantic proximity Read ↗

Paternal deletion of Meg1/Grb10 DMR causes maternalization of the Meg1/Grb10 cluster in mouse proximal Chromosome 11 leading to severe pre- and postnatal growth retardationSemantic proximity Read ↗

PEG10 loss of function causes Silver-Russell syndrome: a familial case with paternal deletion.Semantic proximity Read ↗

Disruption of the imprinted Grb10 gene leads to disproportionate overgrowth by an Igf2-independent mechanism.Semantic proximity Read ↗

Reciprocal imprinting of human GRB10 in placental trophoblast and brain: evolutionary conservation of reversed allelic expression.Semantic proximity Read ↗

Evidence against GRB10 as the gene responsible for Silver-Russell syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.