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Article

Localization of PKA phosphorylation site, Ser(2030), in the three-dimensional structure of cardiac ryanodine receptor.

The Biochemical journal - 1 Mar 2008

Jones Peter P, Meng Xing, Xiao Bailong, Cai Shitian, Bolstad Jeff, Wagenknecht Terence, Liu Zheng, Chen S R Wayne

Abstract excerpt

PKA (protein kinase A)-dependent phosphorylation of the cardiac Ca2+-release channel/RyR2 (type 2 ryanodine receptor)is believed to directly dissociate FKBP12.6 (12.6 kDa FK506-binding protein) from the channel, causing abnormal channel activation and Ca2+ release. To gain insight into the structural basis of the regulation of RyR2 by PKA, we determined the three-dimensional location of the PKA site Ser2030. GFP...

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Identifiers

PMID: 17967164
DOI: 10.1042/BJ20071257
PMCID: PMC2791347

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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