Article
Localization of a K+ -binding site involved in dephosphorylation of the sarcoplasmic reticulum Ca2+ -ATPase.
The Journal of biological chemistry - 5 Nov 2004
Sørensen Thomas Lykke-Møller, Clausen Johannes D, Jensen Anne-Marie Lund, Vilsen Bente, Møller Jesper Vuust, Andersen Jens Peter, Nissen Poul
Abstract excerpt
K+ plays an important role for the function of the sarco(endo)plasmic reticulum Ca2+ -ATPase (SERCA), but its binding site within the molecule has remained unidentified. We have located the binding site for a K+ ion in the P-domain by means of x-ray crystallography using crystals prepared in the presence of the K+ congener Rb+. Backbone carbonyls from the loop containing residues 711-715 together with the side...
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