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Article

New rationales for using TGF<b>beta</b>inhibitors in radiotherapy

1 Jan 2007

Abstract excerpt

PURPOSE: The first reports that ionizing radiation (IR) induces rapid and persistent activation of transforming growth factor beta1 (TGFbeta) were nearly two decades ago. Subsequent studies have shown that TGFbeta is a major mediator of cellular and tissue responses to IR and have revealed novel facets of its complex biology. RESULTS: We and others have recently shown that inhibition of production or signaling of...

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PMID: 18058368
DOI: 10.1080/09553000701711063

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