Article
Development of an AT2-deficient proximal tubule cell line for transport studies.
In vitro cellular & developmental biology. Animal - 1 Jan 2000
Woost Philip G, Kolb Robert J, Chang Chung-Ho, Finesilver Margaret, Inagami Tadashi, Hopfer Ulrich
Abstract excerpt
Angiotensin II is a major regulatory peptide for proximal tubule Na(+) reabsorption acting through two distinct receptor subtypes: AT(1) and AT(2). Physiological or pathological roles of AT(2) have been difficult to unravel because angiotensin II can affect Na(+) transport either directly via AT(2) on luminal or peritubular plasma membranes of proximal tubule cells or indirectly via the renal vasculature....
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