Article
Strategy for the development of a matched set of transport-competent, angiotensin receptor-deficient proximal tubule cell lines.
In vitro cellular & developmental biology. Animal - 1 Jan 2000
Woost Philip G, Kolb Robert J, Finesilver Margaret, Mackraj Irene, Imboden Hans, Coffman Thomas M, Hopfer Ulrich
Abstract excerpt
In the proximal convoluted tubule (PCT) angiotensin II (Ang II) modulates fluid and electrolyte transport through at least two pharmacologically distinct receptor subtypes: AT(1) and AT(2). Development of cell lines that lack these receptors are potentially useful models to probe the complex cellular details of Ang II regulation. To this end, angiotensin receptor- deficient mice were bred with an Immortomouse(R),...
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