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Article

Effect of a thrombin receptor (protease-activated receptor 1, PAR-1) gene polymorphism in chronic hepatitis C liver fibrosis.

Journal of gastroenterology and hepatology - 1 Sept 2008

Martinelli Ana, Knapp Susanne, Anstee Quentin, Worku Mulugeta, Tommasi Anna, Zucoloto Sergio, Goldin Robert, Thursz Mark

Abstract excerpt

BACKGROUND AND AIM: Tissue injury leads to activation of coagulation and generation of thrombin. Inhibition of thrombin receptor protease-activated receptor 1 (PAR-1) has been shown to reduce liver fibrosis in animals. This study aimed to evaluate the effect of PAR-1 gene polymorphism on rate of...

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Source

Identifiers

PMID: 18005014
DOI: 10.1111/j.1440-1746.2007.05220.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18005014-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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