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Article

Increased hepatic fibrosis and JNK2-dependent liver injury in mice exhibiting hepatocyte-specific deletion of cFLIP.

American journal of physiology. Gastrointestinal and liver physiology - 15 Aug 2012

Schattenberg Jörn M, Nagel Michael, Kim Yong Ook, Kohl Tobias, Wörns Marcus A, Zimmermann Tim, Schad Arno, Longerich Thomas, Schuppan Detlef, He You-Wen, Galle Peter R, Schuchmann Marcus

Abstract excerpt

Chronic liver disease promotes hepatocellular injury involving apoptosis and triggers compensatory regeneration that leads to the activation of quiescent stellate cells in the liver. The deposition of extracellular matrix from activated myofibroblasts promotes hepatic fibrosis and the progression to cirrhosis with deleterious effects on liver physiology. The role of apoptosis signaling pathways in the development...

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Identifiers

PMID: 22700824
DOI: 10.1152/ajpgi.00525.2011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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