Article
Acetylcholinesterase (AChE) gene modification in transgenic animals: functional consequences of selected exon and regulatory region deletion.
Chemico-biological interactions - 15 Dec 2005
Camp Shelley, Zhang Limin, Marquez Michael, de la Torre Brian, Long Jeffery M, Bucht Goran, Taylor Palmer
Abstract excerpt
AChE is an alternatively spliced gene. Exons 2, 3 and 4 are invariantly spliced, and this sequence is responsible for catalytic function. The 3' alternatively spliced exons, 5 and 6, are responsible for AChE disposition in tissue [J. Massoulie, The origin of the molecular diversity and functional anchoring of cholinesterases. Neurosignals 11 (3) (2002) 130-143; Y. Li, S. Camp, P. Taylor, Tissue-specific...
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