Article
Ca2+ binding protein-1 inhibits Ca2+ currents and exocytosis in bovine chromaffin cells.
Journal of biomedical science - 1 Mar 2008
Chen Ming-Ling, Chen Yong-Cyuan, Peng I-Wei, Kang Ruo-Lin, Wu Meng-Pei, Cheng Po-Wen, Shih Po-Yuan, Lu Li-Long, Yang Chih-Cheng, Pan Chien-Yuan
Abstract excerpt
Calcium binding protein-1 (CaBP1) is a calmodulin like protein shown to modulate Ca2+ channel activities. Here, we explored the functions of long and short spliced CaBP1 variants (L- and S-CaBP1) in modulating stimulus-secretion coupling in primary cultured bovine chromaffin cells. L- and S-CaBP1 were cloned from rat brain and fused with yellow fluorescent protein at the C-terminal. When expressed in chromaffin...
Topics
- Animals
- Calcium
- Calcium-Binding Proteins
- Cattle
- Cell Line
- Cell Membrane
- Cerebral Cortex
- Chromaffin Cells
- Embryo, Mammalian
- Exocytosis
- Female
- Green Fluorescent Proteins
- Humans
- Membrane Potentials