Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A perforated patch-clamp study of calcium currents and exocytosis in chromaffin cells of wild-type and alpha(1A) knockout mice.

Journal of neurochemistry - 1 Jun 2002

Aldea Marcos, Jun Kisun, Shin Hee-Sup, Andrés-Mateos Eva, Solís-Garrido Luisa M, Montiel Carmen, García Antonio G, Albillos Almudena

Abstract excerpt

Simultaneous recordings of inward whole-cell Ca(2+) channel currents (I(Ca) ) and increments of capacitance as an indication of exocytosis (Delta(Cm)), were performed in voltage-clamped single adrenal chromaffin cells from wild-type and alpha(1A) subunit deficient mice, using the perforated-patch configuration of the patch-clamp technique. Using protocol #1 (one single Ca(2+) channel blocker per cell), to dissect...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium Channel Blockers
Share to Calcium Channels

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Calcium Channels, L-Type

Share to Calcium Channels, N-Type

Share to Chromaffin Cells

Share to Electric Stimulation

Share to Exocytosis

Share to Nifedipine

Source

Identifiers

PMID: 12065603
DOI: 10.1046/j.1471-4159.2002.00845.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A perforated patch-clamp study of calcium currents and exocytosis in chromaffin cells of wild-type and alpha(1A) knockout mice.PMID 12065603Read ↗

Plasticity and adaptation of Ca2+ signaling and Ca2+-dependent exocytosis in SERCA2(+/-) mice.Semantic proximity Read ↗

Whole-cell and single-channel analysis of P-type calcium currents in cerebellar Purkinje cells of leaner mutant mice.Semantic proximity Read ↗

Heterogenous impairment of α-cell function in type 2 diabetes is linked to cell maturation stateSemantic proximity Read ↗

The leaner P/Q-type calcium channel mutation renders cerebellar Purkinje neurons hyper-excitable and eliminates Ca2+-Na+ spike bursts.Semantic proximity Read ↗

Analysis of SCAMP1 function in secretory vesicle exocytosis by means of gene targeting in mice.Semantic proximity Read ↗

Loss of α2δ-1 Calcium Channel Subunit Function Increases the Susceptibility for Diabetes.Semantic proximity Read ↗

Deletion of Orai2 augments endogenous CRAC currents and degranulation in mast cells leading to enhanced anaphylaxis.Semantic proximity Read ↗

Alterations in intracellular calcium ion concentrations in cerebellar granule cells of the CACNA1A mutant mouse, leaner, during postnatal development.Semantic proximity Read ↗

Functional expression of a pseudohypoaldosteronism type I mutated epithelial Na+ channel lacking the pore-forming region of its α subunitSemantic proximity Read ↗

Age-dependent contribution of P/Q- and R-type Ca2+ channels to neuromuscular transmission in lethargic mice.Semantic proximity Read ↗

Altered calcium homeostasis in cerebellar Purkinje cells of leaner mutant mice.Semantic proximity Read ↗

Ca2+ binding protein-1 inhibits Ca2+ currents and exocytosis in bovine chromaffin cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.