Article
Drosophila CtBP regulates proliferation and differentiation of eye precursors and complexes with Eyeless, Dachshund, Dan, and Danr during eye and antennal development.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Sept 2010
Hoang Chinh Q, Burnett Micheal E, Curtiss Jennifer
Abstract excerpt
Specification factors regulate cell fate in part by interacting with transcriptional co-regulators like CtBP to regulate gene expression. Here, we demonstrate that CtBP forms a complex or complexes with the Drosophila melanogaster Pax6 homolog Eyeless (Ey), and with Distal antenna (Dan), Distal antenna related (Danr), and Dachshund to promote eye and antennal specification. Phenotypic analysis together with...
Topics
- Alcohol Oxidoreductases
- Amino Acid Sequence
- Animals
- Arthropod Antennae
- Cell Differentiation
- Cell Proliferation
- DNA-Binding Proteins
- Drosophila
- Drosophila Proteins
- Gene Expression Regulation, Developmental