Article
Xenopus pax6 mutants affect eye development and other organ systems, and have phenotypic similarities to human aniridia patients.
Developmental biology - 15 Dec 2015
Nakayama Takuya, Fisher Marilyn, Nakajima Keisuke, Odeleye Akinleye O, Zimmerman Keith B, Fish Margaret B, Yaoita Yoshio, Chojnowski Jena L, Lauderdale James D, Netland Peter A, Grainger Robert M
Abstract excerpt
Mutations in the Pax6 gene cause ocular defects in both vertebrate and invertebrate animal species, and the disease aniridia in humans. Despite extensive experimentation on this gene in multiple species, including humans, we still do not understand the earliest effects on development mediated by this gene. This prompted us to develop pax6 mutant lines in Xenopus tropicalis taking advantage of the utility of the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.