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Article

Hepatitis B virus genetic diversity and its impact on diagnostic assays.

Journal of viral hepatitis - 1 Nov 2007

Hollinger F B

Abstract excerpt

Hepatitis B virus (HBV) circulates in blood as closely related, but genetically diverse molecules called quasispecies. During replication, HBV production may approach 10(11) molecules/day, although during peak activity this rate may increase 100-1000 times. Generally, DNA polymerases have excellent fidelity in reading DNA templates because they are associated with an exonuclease which removes incorrectly added...

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PMID: 17958637
DOI: 10.1111/j.1365-2893.2007.00910.x

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