Article
[Oncogene-directed mutagenesis in vivo. Polyalkylating derivatives of short single-stranded polynucleotides, complementary E1-adeno-oncogene, in the normalization of adenovirus-transformed rodent cell lines].
Molekuliarnaia biologiia - 1 Jan 2000
Pantin V I, Solov'ev G Ia, Sats N V, Surin V L, Borovkova T V, Krutov A A, Zhukova E L, Grineva N I
Abstract excerpt
Polyalkylating derivatives of single-stranded polynucleotides (30-200-mers) complementary to the long E1 oncogene sequences of simian adenovirus SA7 cause inherited normalization of SH2 and G11 cells transformed with adenovirus SA7; certain deletions in the integrated proviral E1A oncogene were o...
Topics
- Adenoviruses, Simian
- Alkylating Agents
- Animals
- Cell Line, Transformed
- Cell Transformation, Viral
- DNA, Single-Stranded
- Mutagenesis, Site-Directed
- Nucleic Acid Hybridization
- Oncogenes
- Phenotype
- Polymerase Chain Reaction
- Rodentia