Article
[Oncogene-directed mutagenesis in vivo. Polyalkylating derivatives of short single-stranded polynucleotides, complementary E1-adeno-oncogene, in the normalization of adenovirus-transformed rodent cell lines].
Molekuliarnaia biologiia - 1 Jan 2000
Pantin V I, Solov'ev G Ia, Sats N V, Surin V L, Borovkova T V, Krutov A A, Zhukova E L, Grineva N I
Abstract excerpt
Polyalkylating derivatives of single-stranded polynucleotides (30-200-mers) complementary to the long E1 oncogene sequences of simian adenovirus SA7 cause inherited normalization of SH2 and G11 cells transformed with adenovirus SA7; certain deletions in the integrated proviral E1A oncogene were observed in several cases during this process. The transformed cells are indifferent to reagents noncomplementary to the...
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