Article
[Mutation process and malignant transformation induced by adenoviruses in mammalian cells].
TSitologiia i genetika - 1 Jan 2000
Lukash L L
Abstract excerpt
Both oncogenic adenovirus (BAV-3) and nononcogenic adenovirus (Ad-1) are able to induce gene mutations in cultured mammalian cells. In the case of equal multiplicity of the infection the frequency of induced mutations is higher in variants with Ad-1. Unlike Ad-1 both mutagenic and transforming effects of BAV-3 are intensified by means of TPA promoters. TPA modifies analogously mutagenic and transforming effect of...
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