[Induction of mutations in mammalian cells by the action of live vaccinal strains of poliomyelitis virus].

Article

[Induction of mutations in mammalian cells by the action of live vaccinal strains of poliomyelitis virus].

TSitologiia i genetika - 1 Jan 2000

Buzhievskaia T I, Lukash L L, Vavilina I V, Rubashevskiĭ E L

Abstract excerpt

The attenuated strains' poliomyelitis virus induces mutagenesis in human and Chinese hamster cultured cells. The mutagenic action of the poliovirus is detected at chromosome and gene levels and directly depends on the multiplicity of cell infection. Possibilities for developing nonmutagenic antiv...

Topics

Animals
Cell Line
Cells, Cultured
Chromosome Aberrations
Cricetinae
Cricetulus
Genes
Humans
Metaphase
Mutation
Poliovirus Vaccine, Inactivated
Poliovirus Vaccine, Oral
Time Factors

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