Article
A genome-wide linkage study in families with major depression and co-morbid unexplained swelling.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Apr 2008
Anderson Carl A, Maclean Alan, Dunnigan Matthew G, Pelosi Anthony J, Murray Valerie, McKee Irene, McDonald George, Burt David W, Morrice David R, Muir Walter J, Visscher Peter M, Blackwood Douglas H R
Abstract excerpt
Major depressive disorder (MDD) is a common heritable condition. The diversity of the phenotype coupled with aetiological and genetic heterogeneity present formidable obstacles in the search for causative genetic loci. Studies of large families with many affected individuals, and the selection of well-defined clinical subgroups of depression, are two ways to reduce this complexity. Unexplained swelling symptoms...
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