Article
Oocyte-specific G-protein-coupled receptor 3 (GPR3): no perturbations found in 82 women with premature ovarian failure (first report).
Fertility and sterility - 1 Oct 2008
Kovanci Ertug, Simpson Joe Leigh, Amato Paula, Rohozinski Jan, Heard Michael J, Bishop Colin E, Carson Sandra A
Abstract excerpt
The oocyte-specific G-protein-coupled receptor 3 (GPR3) gene is essential in maintaining meiotic arrest in mouse oocytes. Disruption of GPR3 results in early depletion of oocytes and thus premature ovarian aging. To determine if mutations of the GPR3 gene were present in 82 predominantly North American caucasian women with premature ovarian failure (POF), we used denaturing high-performance liquid chromatography...
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