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Article

Utilization of Whole Exome Sequencing in Non-Syndromic Premature Ovarian Failure: Ficolin-3 Gene Mutation in an Iranian Family

Iranian biomedical journal - 1 Nov 2021

Mehrjooy Soophia, Nikbakht Roshan, Mohammadi Asl Javad, Ghadiri Ataallah, Ghandil Pegah

Abstract excerpt

Background: Premature ovarian failure is a heterogeneous disorder, leading to early menopause. Several genes have been identified as the cause of non-syndromic premature ovarian failure (POF). Our aim was to explore the genetic defects in Iranian patients with POF. Methods: We studied a family with three females exhibiting non-syndromic POF. WES was performed for one of the affected individuals after ruling out...

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PMID: 34641644
DOI: 10.52547/ibj.25.6.441
PMCID: PMC8744700

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