Article
Mutational screening of FOXO3A and FOXO1A in women with premature ovarian failure.
Fertility and sterility - 1 Nov 2006
Watkins Wendy J, Umbers Alexandra J, Woad Kathryn J, Harris Sarah E, Winship Ingrid M, Gersak Ksenija, Shelling Andrew N
Abstract excerpt
FOXO3A and FOXO1A are excellent candidate genes for the development of premature ovarian failure and have not been analyzed previously in POF patients. Potentially causal mutations in FOXO3A (2/90; 2.2%) and FOXO1A (1/90; 1.1%) were identified in POF patients; however, the pathological role of these mutations will be determined only by screening increased numbers of patients and controls, or by functional studies.
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